OCA Atlas for 1HSB
1HSB Histocompatibility Antigen date Mar 30, 1993
authors H.-C.Guo, T.S.Jardetzky, T.P.J.Garrett, W.S.Lane, J.L.Strominger, D.C.Wiley
compound source
Class I Histocompatibility Antigen Aw68.1 (Leucocyte Antigen)
 Human (Homo Sapiens) Lymphoblastoid Cell Line Lb
symmetry Space Group: P 21 21 21
R_factor 0.220
crystal
cell
length a length b length c angle alpha angle beta angle gamma
59.430 78.469 111.904 90.00 90.00 90.00
method X-Ray Diffractionresolution 1.9 Å
related structures by homologous chain: 1TMC
similarity Belongs to the MHC_I family.
subunit Dimer of alpha chain and a beta chain (beta-2- microglobulin).
polymorphism A*6804, a*6805, a*6806, a*6807, a*6808, a*6809, a*6810, a*6816 and a*6817. The following alleles of a*68 are known (aw68.1), a*6802, a*6803. The sequence shown is that of a*6801.
genes HLA-A, HLAA (H. sapiens)
function Involved in the presentation of foreign antigens to the immune system.
Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (86 Kb) [Save to disk]
  • CSU: Contacts of Structural Units for 1HSB
  • Likely Quarternary Molecular Structure file(s) for 1HSB
  • Retrieve 1HSB in mmCIF format [Save to disk]
    • View 1HSB in 3D
  • Protein Explorer, Easier to use and more powerful than RasMol. (Win and Mac only)
  • FirstGlance in Chemscape Chime (Install Chime freeware) This is good for easiest viewing of basic structure.
  • RasMol (Install RasMol freeware) Here's help on how to use RasMol.
    • Visual 3D analysis of 1HSB
  • STING, shows the sequence and maps the locations of sequence residues or residue ranges onto the 3D structure.
  • Noncovalent Bond Finder displays the closest contacts to ligand or interface, reports distances, walks over water bridges.
  • GRASS (Graphical Representation and Analysis of Structure Server)
    • View 1HSB in 2D
  • Topology of domains/folds: Chain: A, Chain: B from TOPS (The Atlas of protein topology cartoons )
    • Structure-derived information
  • Dipole moment, from Dipole Server at Weizmann Institute
  • Genome occurence of 1HSB's fold from GeneCensus
  • Classification of representative domains in scop (Structural Classification of Proteins)
        - Domain d1hsba2, region A:1-181 [rasmolscript] [script source]
        - Domain d1hsba1, region A:182-270 [rasmolscript] [script source]
        - Domain d1hsbb1, region B: [rasmolscript] [script source]
  • Fold representative 1hsb from FSSP and Dali (Families of Structurally Similar Proteins)
  • Domain Definition for 1hsb from 3Dee ( The Database of Protein Domain Definitions )
  • Class (fold), Architecture (subfold), Topology, Homologous superfamily: CATH
  • Summaries and structural analyses of PDB data files: PDBSum
    • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [1hsb_A] [1hsb_B] [1hsb_C] [1hsb_D]
  • SWISS-PROT database: [1A68_HUMAN]
  • Domain organization of [1A68_HUMAN] by SWISSPFAM
  • Domain found in 1HSB: [IGc1 ] by SMART
  • Conserved protein region description, domain view and alignment from family MHC_I (PF00129) of Pfam.
  • Alignments of the sequence of 1HSB with the sequences similar proteins can be viewed for classification [1A68_HUMAN] at ProtoMap. Click on "Neighbors List", then on the "See Alignments" button below the list.
  • A sequence distance tree ("phylogenetic tree") can be viewed for 1ACL's classification [1A68_HUMAN] at ProtoMap. Click on the Cluster number.
    • Other resources with information on 1HSB
  • InterPro: IPR003006 , IPR001039 , IPR003597
  • PDBREPORT (protein verification by WHAT_CHECK procedures)
  • MMDB (Entrez's Structure Database)
    • Movements, Movies and Images
  • Images from IMB Jena Image Library of Biological Macromolecules.

    • You may enter another PDB ID code
    Go [Back], to the [PDB Lite page], to the [OCA Search page] or to the [PDB Home page]