OCA Atlas for 1HHK
1HHK Histocompatibility Antigen date Jun 30, 1993
authors D.R.Madden, D.N.Garboczi, D.C.Wiley
compound source
Human Class I Histocompatibility Antigen (Hla-A 0201) Complex With A Nonameric Peptide From Htlv-1 Tax Protein (Residues 11-19)
 Human (Homo Sapiens) Recombinant Form. Extracellular Fragment Expressed In (Escherichia Coli) And Reconstituted With Synthetic Peptide
symmetry Space Group: P 1
R_factor 0.262
crystal
cell
length a length b length c angle alpha angle beta angle gamma
50.560 63.790 75.080 81.58 75.66 77.38
method X-Ray Diffractionresolution 2.5 Å
related structures by homologous chain: 1B0G, 1HHI
similarity Belongs to the MHC_I family.
subunit Dimer of alpha chain and a beta chain (beta-2- microglobulin).
polymorphism The following alleles of a-2 are known a*0202, a*0203, a*0204, a*0205, a*0206 (a2.4a), a*0207, a*0208, a*0209, a*0210, a*0211 (a2.5), a*0212, a*0213 (a*02slu), a*0216, a*0217, a*0218 (a2k), a*0219, a*0220 and a*0221. The sequence shown is that of a*0201.
genes HLA-A, HLAA (H. sapiens)
function Involved in the presentation of foreign antigens to the immune system.
Data retrieval
  • Asymmetric unit, PDB entry: [header only] [complete with coordinates] (158 Kb) [Save to disk]
  • CSU: Contacts of Structural Units for 1HHK
  • Likely Quarternary Molecular Structure file(s) for 1HHK
  • Retrieve 1HHK in mmCIF format [Save to disk]
    • View 1HHK in 3D
  • Protein Explorer, Easier to use and more powerful than RasMol. (Win and Mac only)
  • FirstGlance in Chemscape Chime (Install Chime freeware) This is good for easiest viewing of basic structure.
  • RasMol (Install RasMol freeware) Here's help on how to use RasMol.
    • Visual 3D analysis of 1HHK
  • STING, shows the sequence and maps the locations of sequence residues or residue ranges onto the 3D structure.
  • Noncovalent Bond Finder displays the closest contacts to ligand or interface, reports distances, walks over water bridges.
  • GRASS (Graphical Representation and Analysis of Structure Server)
    • View 1HHK in 2D
  • Topology of domains/folds: Chain: A, Chain: B, Chain: D, Chain: E from TOPS (The Atlas of protein topology cartoons )
    • Structure-derived information
  • Dipole moment, from Dipole Server at Weizmann Institute
  • Genome occurence of 1HHK's fold from GeneCensus
  • Classification of representative domains in scop (Structural Classification of Proteins)
        - Domain d1hhka2, region A:1-181 [rasmolscript] [script source]
        - Domain d1hhka1, region A:182-275 [rasmolscript] [script source]
        - Domain d1hhkb1, region B: [rasmolscript] [script source]
        - Domain d1hhkd2, region D:1-181 [rasmolscript] [script source]
        - Domain d1hhkd1, region D:182-275 [rasmolscript] [script source]
        - Domain d1hhke1, region E: [rasmolscript] [script source]
  • Fold representative 1hhk from FSSP and Dali (Families of Structurally Similar Proteins)
  • Domain Definition for 1hhk from 3Dee ( The Database of Protein Domain Definitions )
  • Class (fold), Architecture (subfold), Topology, Homologous superfamily: CATH
  • Summaries and structural analyses of PDB data files: PDBSum
    • Sequence-derived information
  • View one-letter amino acid or nucleotide sequence for each chain: [1hhk_A] [1hhk_B] [1hhk_C] [1hhk_D] [1hhk_E] [1hhk_F]
  • SWISS-PROT database: [1A02_HUMAN]
  • Domain organization of [1A02_HUMAN] by SWISSPFAM
  • Domain found in 1HHK: [IGc1 ] by SMART
  • Conserved protein region description, domain view and alignment from family MHC_I (PF00129) of Pfam.
  • Alignments of the sequence of 1HHK with the sequences similar proteins can be viewed for classification [1A02_HUMAN] at ProtoMap. Click on "Neighbors List", then on the "See Alignments" button below the list.
  • A sequence distance tree ("phylogenetic tree") can be viewed for 1ACL's classification [1A02_HUMAN] at ProtoMap. Click on the Cluster number.
    • Other resources with information on 1HHK
  • InterPro: IPR003006 , IPR001039
  • PDBREPORT (protein verification by WHAT_CHECK procedures)
  • MMDB (Entrez's Structure Database)
    • Movements, Movies and Images
  • Images from IMB Jena Image Library of Biological Macromolecules.

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