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  ISSPred            Intein Splice Site Prediction

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In the modern era, process of protein expression is further complexed by the addition of new Post-translational Modification events such as proteolytic cleavage of polyproteins, proteome mediated peptide ligation, non-ribosomal addition of moieties and intein mediated protein splicing.

Protein splicing is a recently discovered Post-translational Modification in which one internal fragment, termed intein (Protein introns), is excised from a precursor protein and the flanking regions, termed extein, ligate to form a mature protein.
The process of precise intein splicing and formation of specific peptide bonds has been tempting scholars to develop many novel applications.

This server is an attempt to help biolgist identify Inteins hiding in their protein sequences.

Contact:  raghava@iiitd.ac.in