Detailed description page of Hmrbase2
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33846 details |
| Primary information | |
|---|---|
| ID | 33846 |
| Uniprot ID | P30991 |
| Description | C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Fusin) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) |
| Organism | Pan troglodytes |
| Txonomy | Pan , Homininae , Hominidae , Hominoidea , Catarrhini , Simiiformes , Haplorrhini , Primates , Euarchontoglires, Boreoeutheria , Eutheria , Theria , Mammalia , Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii, Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata , Chordata , Deuterostomia , Bilateria , Eumetazoa , Metazoa, Opisthokonta , Eukaryota , cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation. |
| Function | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). |
| Length | 352 |
| Molecular Weight | 39746 |
| Reference | NA |
| Hormone | P48061 |
| PDB ID | NA |