Detailed description page of Hmrbase2
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33835 details |
| Primary information | |
|---|---|
| ID | 33835 |
| Uniprot ID | B2ZI34 |
| Description | Neuromedin-B receptor (NMB-R) (Neuromedin-B-preferring bombesin receptor) |
| Organism | Sus scrofa |
| Txonomy | Sus , Suidae , Suina , Artiodactyla , Laurasiatheria, Boreoeutheria , Eutheria , Theria , Mammalia , Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii, Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata , Chordata , Deuterostomia , Bilateria , Eumetazoa , Metazoa, Opisthokonta , Eukaryota , cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | During the sow estrus cycle, highest levels are found in the hypothalamus at proestrus and estrus with a significant drop at metestrus and an increase at diestrus. In the pituitary gland, expression increases from proestrus to estrus, drops at metestrus and increases at diestrus. In the ovary, expre |
| Similarity | NA |
| Post Translational Modification | NA |
| Function | Receptor for neuromedin-B (By similarity). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (By similarity). Plays a role in CSF1-induced prolifer |
| Length | 390 |
| Molecular Weight | 43328 |
| Reference | NA |
| Hormone | NA |
| PDB ID | NA |