| Txonomy | Homo , Homininae , Hominidae , Hominoidea , Catarrhini , Simiiformes , Haplorrhini , Primates , Euarchontoglires, Boreoeutheria , Eutheria , Theria , Mammalia , Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii, Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata , Chordata , Deuterostomia , Bilateria , Eumetazoa , Metazoa, Opisthokonta , Eukaryota , cellular organisms |
| Function | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (Ref.11). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of fre |