Detailed description page of Hmrbase2
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33823 details |
| Primary information | |
|---|---|
| ID | 33823 |
| Uniprot ID | P48442 |
| Description | Extracellular calcium-sensing receptor (CaSR) (Parathyroid cell calcium-sensing receptor) (PCaR1) (RaKCaR) |
| Organism | Rattus norvegicus |
| Txonomy | Rattus , Murinae , Muridae , Muroidea , Myomorpha , Rodentia , Glires , Euarchontoglires, Boreoeutheria , Eutheria , Theria , Mammalia , Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii, Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata , Chordata , Deuterostomia , Bilateria , Eumetazoa , Metazoa, Opisthokonta , Eukaryota , cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | N-glycosylated. |
| Function | G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7816802). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (By similarity). |
| Length | 1079 |
| Molecular Weight | 120868 |
| Reference | NA |
| Hormone | P0C172 |
| PDB ID | NA |