| Txonomy | melanogaster subgroup , melanogaster group , Sophophora (subgenus), Drosophila , Drosophilini (tribe), Drosophilinae , Drosophilidae , Ephydroidea , Acalyptratae , Schizophora , Cyclorrhapha , Eremoneura , Muscomorpha , Brachycera , Diptera , Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia , Insecta , Hexapoda , Pancrustacea , Mandibulata , Arthropoda , Panarthropoda , Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa, Opisthokonta , Eukaryota , cellular o |
| Function | Receptor for NPF. Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to diverse stressful stimuli (chemical stress and noxious heat) through attenuation of TRP channel-induced neuronal excitation. NPF neural signaling system plays a physiological role in acute modulation of alcohol sensitivity in adults, rather than a general response to intoxication by sedative agents. Activation and inhibition of the NPF system reduces and enhances ethanol preference, respectively. Sexual |