Detailed description page of Hmrbase2
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33815 details |
| Primary information | |
|---|---|
| ID | 33815 |
| Uniprot ID | Q13324-2 |
| Description | Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2) |
| Organism | Homo sapiens |
| Txonomy | Homo , Homininae , Hominidae , Hominoidea , Catarrhini , Simiiformes , Haplorrhini , Primates , Euarchontoglires, Boreoeutheria , Eutheria , Theria , Mammalia , Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii, Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata , Chordata , Deuterostomia , Bilateria , Eumetazoa , Metazoa, Opisthokonta , Eukaryota , cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | A N-glycosylation site within the signal peptide impedes its proper cleavage and function. |
| Function | G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. |
| Length | 411 |
| Molecular Weight | 47688 |
| Reference | NA |
| Hormone | P55089; Q96RP3; Q969E3 |
| PDB ID | NA |