| Primary information |
|---|
| ID | 33813 |
| Uniprot ID | P22273 |
| Description | Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (CD antigen CD126) [Cleaved into- Soluble interleukin-6 receptor subunit alpha |
| Organism | Rattus norvegicus |
| Txonomy | Rattus ; Murinae ; Muridae ; Muroidea ; Myomorpha ; Rodentia ; Glires ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | [Interleukin-6 receptor subunit alpha]- Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | A short soluble form is also released from the membrane by proteolysis. The sIL6R is formed by limited proteolysis of membrane-bound receptors; a process referred to as ectodomain shedding. mIL6R is cleaved by the proteases ADAM10 and ADAM17. |
| Function | Part of the receptor for interleukin 6. Binds to IL6 with low affinity; but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response; acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling'; the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively; 'cluster signaling' occurs when membrane-bound IL6-IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. |
| Length | 462 |
| Molecular Weight | 50401 |
| Reference | 2174054 |
| Hormone | NA |
| PDB ID | NA
|