| Primary information |
|---|
| ID | 33796 |
| Uniprot ID | Q63772 |
| Description | Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand) (Growth-potentiating factor) (GPF) |
| Organism | Rattus norvegicus |
| Txonomy | Rattus ; Murinae ; Muridae ; Muroidea ; Myomorpha ; Rodentia ; Glires ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium (Probable). |
| Function | Ligand for tyrosine-protein kinase receptors AXL; TYRO3 and MER whose signaling is implicated in cell growth and survival; cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis; optimal cytokine signaling during human natural killer cell development; hepatic regeneration; gonadotropin-releasing hormone neuron survival and migration; platelet activation; or regulation of thrombotic responses. |
| Length | 674 |
| Molecular Weight | 74638 |
| Reference | 7890695; 7559388; 89 |
| Hormone | NA |
| PDB ID | NA
|