| Primary information |
|---|
| ID | 33794 |
| Uniprot ID | P19235 |
| Description | Erythropoietin receptor (EPO-R) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein.; [Isoform EPOR-S]- Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | On EPO stimulation; phosphorylated on C-terminal tyrosine residues by JAK2. The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation. Phosphorylation on Tyr-454 is required for PTPN6 interaction; Tyr-426 for PTPN11. Tyr-426 is also required for SOCS3 binding; but Tyr-454/Tyr-456 motif is the preferred binding site. |
| Function | Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation; EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types; can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.; Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling. |
| Length | 508 |
| Molecular Weight | 55065 |
| Reference | 2163695; 2163696; 16 |
| Hormone | NA |
| PDB ID | NA
|