| Primary information |
|---|
| ID | 33522 |
| Uniprot ID | O42602 |
| Description | Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1) |
| Organism | Xenopus laevis |
| Txonomy | Xenopus (subgenus); Xenopus ; Xenopodinae ; Pipidae ; Pipoidea ; Anura ; Batrachia ; Amphibia ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | NA |
| Function | G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors; such as adenylate cyclase. Promotes the activation of adenylate cyclase; leading to increased intracellular cAMP levels. |
| Length | 415 |
| Molecular Weight | 47786 |
| Reference | 9326293 |
| Hormone | NA |
| PDB ID | NA
|