| Primary information |
|---|
| ID | 33501 |
| Uniprot ID | Q98867 |
| Description | Thyroid hormone receptor alpha-A (zTRalpha-A) (Nuclear receptor subfamily 1 group A member 1-A) (Thyroid hormone receptor alpha-1) (TRalpha-1) |
| Organism | Danio rerio |
| Txonomy | Danio ; Danioninae ; Danionidae ; Cyprinoidei ; Cypriniformes ; Cypriniphysae ; Otophysi ; Ostariophysi (subcohort); Otomorpha (cohort); Clupeocephala ; Osteoglossocephalai ; Teleostei (infraclass); Neopterygii (subclass); Actinopteri ; Actinopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Nucleus |
| Developmental Stage | Expressed both maternally and zygotically. Most abundant during early oogenesis during stages I and II; and expression levels drop by oocyte maturation. Expressed at the 1-cell stage and then again after the MBT from the blastula to early gastrula (shield) stages; during which expression levels decr |
| Similarity | NA |
| Post Translational Modification | NA |
| Function | High affinity receptor for triiodothyronine. In the absence of thyroid hormone during late blastula stage development; acts as a transcriptional repressor. Whereas in the presence of thyroid hormone; can act as an activator of transcription. In addition; represses retinoic acid (RA)-signaling during blastula and gastrula stages of development. |
| Length | 427 |
| Molecular Weight | 48728 |
| Reference | 9447705; 23594743; 1 |
| Hormone | NA |
| PDB ID | NA
|