| Primary information |
|---|
| ID | 33497 |
| Uniprot ID | Q92570 |
| Description | Nuclear receptor subfamily 4 group A member 3 (Mitogen-induced nuclear orphan receptor) (Neuron-derived orphan receptor 1) (Nuclear hormone receptor NOR-1) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Nucleus |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Phosphorylated by PRKDC. |
| Function | Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes. Plays a role in the regulation of proliferation; survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle; myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site. Upon PDGF stimulation; stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets; induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle; as well as genes that cause degrada |
| Length | 626 |
| Molecular Weight | 68230 |
| Reference | 8809112; 8614405; 85 |
| Hormone | NA |
| PDB ID | NA
|