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33494 details
Primary information
ID33494
Uniprot IDQ8SPP9
DescriptionThyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)
OrganismSus scrofa
TxonomySus ; Suidae ; Suina ; Artiodactyla ; Laurasiatheria ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms
Subcellular LocationCell membrane
Developmental StageNA
SimilarityNA
Post Translational ModificationGlycosylated.
FunctionReceptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2-GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Length764
Molecular Weight86644
Reference12880144; 11847099
HormoneNA
PDB IDNA