| Primary information |
|---|
| ID | 33470 |
| Uniprot ID | Q13324 |
| Description | Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | A N-glycosylation site within the signal peptide impedes its proper cleavage and function. |
| Function | G-protein coupled receptor for CRH (corticotropin-releasing factor); UCN (urocortin); UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors; such as adenylate cyclase. Promotes the activation of adenylate cyclase; leading to increased intracellular cAMP levels. |
| Length | 411 |
| Molecular Weight | 47688 |
| Reference | 8536644; 9717834; 14 |
| Hormone | NA |
| PDB ID | NA
|