| Primary information |
|---|
| ID | 33430 |
| Uniprot ID | P35353 |
| Description | Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1) |
| Organism | Rattus norvegicus |
| Txonomy | Rattus ; Murinae ; Muridae ; Muroidea ; Myomorpha ; Rodentia ; Glires ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Endosome |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | C-terminal Ser or Thr residues may be phosphorylated.; Phosphorylation at Ser-301 by PKA prevents maximal coupling to Gq-protein; and thereby negatively regulates downstream signaling. |
| Function | G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors; such as adenylate cyclase. Promotes the activation of adenylate cyclase; leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. |
| Length | 415 |
| Molecular Weight | 47842 |
| Reference | 8243338; 8274282; 86 |
| Hormone | NA |
| PDB ID | NA
|