| Primary information |
|---|
| ID | 33407 |
| Uniprot ID | P16882 |
| Description | Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into- Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)] |
| Organism | Mus musculus |
| Txonomy | Mus (subgenus); Mus ; Murinae ; Muridae ; Muroidea ; Myomorpha ; Rodentia ; Glires ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding; GHR is ubiquitin |
| Developmental Stage | During gestation; both hepatic and serum expression begins at day 9. Levels increased 8-fold in liver and 30-fold in serum by late gestation. Levels of isoform 1 and isoform 2 similarly begin at day 9 with isoform 1 expression reaching maximum levels by day 13; isoform 2 levels continue to increase |
| Similarity | NA |
| Post Translational Modification | On GH binding; phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2. |
| Function | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding; couples to; and activates the JAK2/STAT5 pathway. |
| Length | 650 |
| Molecular Weight | 72783 |
| Reference | 2739661; 7988474; 10 |
| Hormone | NA |
| PDB ID | NA
|