| Primary information |
|---|
| ID | 33400 |
| Uniprot ID | P12813 |
| Description | Nuclear receptor subfamily 4 group A member 1 (Nuclear hormone receptor NUR/77) (Nuclear protein N10) (Orphan nuclear receptor HMR) |
| Organism | Mus musculus |
| Txonomy | Mus (subgenus); Mus ; Murinae ; Muridae ; Muroidea ; Myomorpha ; Rodentia ; Glires ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Nucleus |
| Developmental Stage | Highest levels are found in the adult with barely detectable levels in pre- and early postnatal tissue. |
| Similarity | NA |
| Post Translational Modification | Phosphorylated at Ser-354 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli. |
| Function | Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus; thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury |
| Length | 601 |
| Molecular Weight | 64738 |
| Reference | 3186734; 2555161; 15 |
| Hormone | NA |
| PDB ID | NA
|