| Primary information |
|---|
| ID | 33321 |
| Uniprot ID | O75084 |
| Description | Frizzled-7 (Fz-7) (hFz7) (FzE3) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Ubiquitinated by ZNRF3; leading to its degradation by the proteasome. |
| Function | Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway; which leads to the activation of disheveled proteins; inhibition of GSK-3 kinase; nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members; but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway; as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes. Following ligand activation; binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling; activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses |
| Length | 574 |
| Molecular Weight | 63620 |
| Reference | 9707618; 15815621; 9 |
| Hormone | NA |
| PDB ID | NA
|