| Primary information |
|---|
| ID | 33320 |
| Uniprot ID | Q9H461 |
| Description | Frizzled-8 (Fz-8) (hFz8) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Membrane; Multi-pass membrane protein. Golgi apparatus |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Ubiquitinated by ZNRF3; leading to its degradation by the proteasome. |
| Function | Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins; inhibition of GSK-3 kinase; nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members; but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway; as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins; such as WNT1. |
| Length | 694 |
| Molecular Weight | 73300 |
| Reference | 11295046; 15164054; |
| Hormone | NA |
| PDB ID | NA
|