| Primary information |
|---|
| ID | 33291 |
| Uniprot ID | Q9BZZ2 |
| Description | Sialoadhesin (Sialic acid-binding Ig-like lectin 1) (Siglec-1) (CD antigen CD169) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | [Isoform 1]- Cell membrane; Single-pass type I membrane protein.; [Isoform 2]- Secreted. |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | NA |
| Function | Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes; including granulocytes; monocytes; natural killer cells; B-cells and CD8 T-cells. Preferentially binds to alpha-2;3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis. |
| Length | 1709 |
| Molecular Weight | 182624 |
| Reference | 11133773; 11780052; |
| Hormone | NA |
| PDB ID | NA
|