| Primary information |
|---|
| ID | 33275 |
| Uniprot ID | P61072 |
| Description | C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Fusin) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) |
| Organism | Pan troglodytes |
| Txonomy | Pan ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH; ubiquitination and protein degradation. |
| Function | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration; e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response; including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract; probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS; could mediate hippocampal-neuron survival. |
| Length | 352 |
| Molecular Weight | 39746 |
| Reference | 9430250 |
| Hormone | NA |
| PDB ID | NA
|