| Primary information |
|---|
| ID | 33273 |
| Uniprot ID | P10721 |
| Description | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma v |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | [Isoform 1]- Cell membrane; Single-pass type I membrane protein.; [Isoform 2]- Cell membrane; Single |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding; leading to internalization and degradation. |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation; hematopoiesis; stem cell maintenance; gametogenesis; mast cell development; migration and function; and in melanogenesis. In response to KITLG/SCF binding; KIT can activate several signaling pathways. Phosphorylates PIK3R1; PLCG1; SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1; the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS; RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1; STAT3; STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. KIT signaling is modulated by protein phosphatases; and by rapid internalization and degradation of the receptor. Activated KIT p |
| Length | 976 |
| Molecular Weight | 109865 |
| Reference | 2448137; 1279499; 75 |
| Hormone | NA |
| PDB ID | NA
|