| Primary information |
|---|
| ID | 33262 |
| Uniprot ID | Q9UM73 |
| Description | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Phosphorylated at tyrosine residues by autocatalysis; which activates kinase activity (PubMed-11121404; PubMed-15938644; PubMed-16878150; PubMed-34819673). In cells not stimulated by a ligand; receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation (PubMed-17681947). Phosphorylation at Tyr-1507 is critical for SHC1 association (PubMed-17274988). |
| Function | Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system |
| Length | 1620 |
| Molecular Weight | 176442 |
| Reference | 9174053; 9053841; 15 |
| Hormone | NA |
| PDB ID | NA
|