| Primary information |
|---|
| ID | 33259 |
| Uniprot ID | P17948 |
| Description | Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeabi |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | [Isoform 1]- Cell membrane; Single-pass type I membrane protein. Endosome. Note=Autophosphorylation |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | N-glycosylated. |
| Function | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA; VEGFB and PGF; and plays an essential role in the development of embryonic vasculature; the regulation of angiogenesis; cell survival; cell migration; macrophage function; chemotaxis; and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (Ref.11). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation; survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells; proliferation of some types of cancer cells; but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of fre |
| Length | 1338 |
| Molecular Weight | 150769 |
| Reference | 2158038; 8248162; 10 |
| Hormone | NA |
| PDB ID | NA
|