| Primary information |
|---|
| ID | 33252 |
| Uniprot ID | Q14118 |
| Description | Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into- Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | [Alpha-dystroglycan]- Secreted; extracellular space.; [Beta-dystroglycan]- Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | [Alpha-dystroglycan]- O-glycosylated. POMGNT1 catalyzes the initial addition of N-acetylglucosamine; giving rise to the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety and thus providing the necessary basis for the addition of further carbohydrate moieties (PubMed-27493216). Heavily O-glycosylated comprising of up to two thirds of its mass and the carbohydrate composition differs depending on tissue type. Mucin-type O-glycosylation is important for ligand binding activity. O-mannosylation is found i |
| Function | The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly; sarcolemmal stability; cell survival; peripheral nerve myelination; nodal structure; cell migration; and epithelial polarization.; [Alpha-dystroglycan]- Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5. |
| Length | 895 |
| Molecular Weight | 97441 |
| Reference | 8268918; 14702039; 1 |
| Hormone | NA |
| PDB ID | NA
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