| Primary information |
|---|
| ID | 33251 |
| Uniprot ID | P28907 |
| Description | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyc |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Membrane; Single-pass type II membrane protein. |
| Developmental Stage | Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow; where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E. |
| Similarity | NA |
| Post Translational Modification | NA |
| Function | Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate; the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. |
| Length | 300 |
| Molecular Weight | 34328 |
| Reference | 2319135; 9074508; 15 |
| Hormone | NA |
| PDB ID | NA
|