| Primary information |
|---|
| ID | 33250 |
| Uniprot ID | Q15116 |
| Description | Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | Induced at programmed cell death. |
| Similarity | NA |
| Post Translational Modification | Ubiquitinated at Lys-233 by the SCF(FBXO38) complex; leading to its proteasomal degradation (PubMed-30487606). Ubiquitinated via 'Lys-48'-linked polyubiquitin chains (PubMed-30487606). |
| Function | Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self |
| Length | 288 |
| Molecular Weight | 31647 |
| Reference | 7851902; 9332365; 12 |
| Hormone | NA |
| PDB ID | NA
|