| Primary information |
|---|
| ID | 33248 |
| Uniprot ID | P16234 |
| Description | Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 ant |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | N-glycosylated.; Ubiquitinated; leading to its internalization and degradation. |
| Function | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA; PDGFB and PDGFC and plays an essential role in the regulation of embryonic development; cell proliferation; survival and chemotaxis. Depending on the context; promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract; and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation; secretion of agonists from platelet granules; and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA; homodimeric PDGFB; heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of sever |
| Length | 1089 |
| Molecular Weight | 122670 |
| Reference | 2544881; 2536956; 85 |
| Hormone | NA |
| PDB ID | NA
|