| Primary information |
|---|
| ID | 33223 |
| Uniprot ID | P04629 |
| Description | High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase rece |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Ligand-mediated autophosphorylation (PubMed-2927393; PubMed-1281417; PubMed-15488758; PubMed-7510697; PubMed-8155326; PubMed-8325889; PubMed-27676246; PubMed-28177573). Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at Tyr-496 mediates interaction and phosphorylation of SHC1 (PubMed-15488758; PubMed-7510697; PubMed-8155326; PubMed-8325889). |
| Function | Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation; differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand |
| Length | 796 |
| Molecular Weight | 87497 |
| Reference | 2927393; 7823156; 92 |
| Hormone | NA |
| PDB ID | NA
|