| Primary information |
|---|
| ID | 33207 |
| Uniprot ID | Q04912 |
| Description | Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into- Macrophage-stimulating protein receptor alpha cha |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Proteolytic processing yields the two subunits.; Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site. |
| Function | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival; migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand; interacts with the PI3-kinase subunit PIK3R1; PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK; PI3 kinase-AKT; or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration; proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively; RON can also promote signals such as cell migration and proliferation in respon |
| Length | 1400 |
| Molecular Weight | 152241 |
| Reference | 8386824; 8816464; 18 |
| Hormone | NA |
| PDB ID | NA
|