| Primary information |
|---|
| ID | 33191 |
| Uniprot ID | P08887 |
| Description | Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into- Soluble in |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | [Isoform 1]- Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | A short soluble form is released from the membrane by proteolysis (PubMed-26876177). The sIL6R is formed mostly by limited proteolysis of membrane-bound receptors; a process referred to as ectodomain shedding; but is also directly secreted from the cells after alternative mRNA splicing (PubMed-26876177; PubMed-28060820). mIL6R is cleaved by the proteases ADAM10 and ADAM17 (PubMed-26876177; PubMed-28060820). |
| Function | Part of the receptor for interleukin 6. Binds to IL6 with low affinity; but does not transduce a signal |
| Length | 468 |
| Molecular Weight | 51548 |
| Reference | 3136546; 1872801; 14 |
| Hormone | NA |
| PDB ID | NA
|