| Primary information |
|---|
| ID | 33189 |
| Uniprot ID | P07333 |
| Description | Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Autophosphorylated in response to CSF1 or IL34 binding (PubMed-24336230; PubMed-20489731; PubMed-23408870). Phosphorylation at Tyr-561 is important for normal down-regulation of signaling by ubiquitination; internalization and degradation. Phosphorylation at Tyr-561 and Tyr-809 is important for interaction with SRC family members; including FYN; YES1 and SRC; and for subsequent activation of these protein kinases. Phosphorylation at Tyr-699 and Tyr-923 is important for interaction with GRB2. Pho |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival; proliferation and differentiation of hematopoietic precursor cells; especially mononuclear phagocytes; such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1; and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation; the regulation of bone resorption; and is required for normal bone and tooth development. Required for normal male and female fertility; and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton; regulates formation of membrane ruffles; cell adhesion and cell migration; and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding; |
| Length | 972 |
| Molecular Weight | 107984 |
| Reference | 2524025; 2421165; 90 |
| Hormone | NA |
| PDB ID | NA
|