| Primary information |
|---|
| ID | 33171 |
| Uniprot ID | P24394 |
| Description | Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into- Soluble interleukin-4 receptor subunit alpha (Soluble |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein.; [Isoform 2]- Secreted. |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | On IL4 binding; phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues; Tyr-575; Tyr-603 or Tyr-631; is required for STAT6-induced gene induction. |
| Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and; chemokine and mucus production at sites of allergic inflammation. In certain cell types; can signal through activation of insulin receptor substrates; IRS1/IRS2. |
| Length | 825 |
| Molecular Weight | 89658 |
| Reference | 2307934; 2278997; 10 |
| Hormone | NA |
| PDB ID | NA
|