| Primary information |
|---|
| ID | 33169 |
| Uniprot ID | Q14626 |
| Description | Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into- Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) ( |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | [Interleukin-11 receptor subunit alpha]- Membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | A short soluble form is also released from the membrane by proteolysis (PubMed-26876177). The sIL11RA is formed either by limited proteolysis of membrane-bound receptors; a process referred to as ectodomain shedding; or directly secreted from the cells after alternative mRNA splicing (PubMed-26876177). mIL11RA is cleaved by the proteases ADAM10; ELANE and PRTN3 (PubMed-26876177). |
| Function | Receptor for interleukin-11 (IL11). The receptor systems for IL6; LIF; OSM; CNTF; IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. |
| Length | 422 |
| Molecular Weight | 45222 |
| Reference | 7670098; 8808281; 15 |
| Hormone | NA |
| PDB ID | NA
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