| Primary information |
|---|
| ID | 33161 |
| Uniprot ID | P08069 |
| Description | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into- Insulin-like growth factor 1 receptor alpha chain; Insuli |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Autophosphorylated on tyrosine residues in response to ligand binding. Autophosphorylation occurs in trans; i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Autophosphorylation occurs in a sequential manner; Tyr-1165 is predominantly phosphorylated first; followed by phosphorylation of Tyr-1161 and Tyr-1166. While every single phosphorylation increases kinase activity; all three tyrosine residues in the kinase activation loop (Tyr-1165; Tyr-1161 and |
| Function | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase; leading to receptor autophosphorylation; and tyrosines phosphorylation of multiple substrates; that function as signaling adapter proteins including; the insulin-receptor substrates (IRS1/2); Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways- the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation; whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1); leading to activation of several downs |
| Length | 1367 |
| Molecular Weight | 154793 |
| Reference | 2877871; 1316909; 16 |
| Hormone | NA |
| PDB ID | NA
|