| Primary information |
|---|
| ID | 33158 |
| Uniprot ID | P15260 |
| Description | Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Phosphorylated at Ser/Thr residues. Phosphorylation of Tyr-457 is required for IFNG receptor signal transduction (PubMed-8156998). Influenza virus infection leads to phosphorylation in a CSNK1A1-dependent manner (PubMed-29343571). |
| Function | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial; antiviral; and antitumor responses by activating effector immune cells and enhancing antigen presentation |
| Length | 489 |
| Molecular Weight | 54405 |
| Reference | 2971451; 14702039; 1 |
| Hormone | NA |
| PDB ID | NA
|