| Primary information |
|---|
| ID | 33157 |
| Uniprot ID | P48551 |
| Description | Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | [Isoform 1]- Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1; STAT2 and STAT3 leading to antiproliferative effects on many different cell types. |
| Function | Together with IFNAR1; forms the heterodimeric receptor for type I interferons (including interferons alpha; beta; epsilon; omega and kappa) |
| Length | 515 |
| Molecular Weight | 57759 |
| Reference | 8181059; 7588638; 76 |
| Hormone | NA |
| PDB ID | NA
|