| Primary information |
|---|
| ID | 33149 |
| Uniprot ID | P35968 |
| Description | Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell junction |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | N-glycosylated. |
| Function | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA; VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis; vascular development; vascular permeability; and embryonic hematopoiesis. Promotes proliferation; survival; migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain; such as isoform 2 and isoform 3; may function as decoy receptors for VEGFA; VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate and the activation of p |
| Length | 1356 |
| Molecular Weight | 151527 |
| Reference | 18593464; 19668192; |
| Hormone | NA |
| PDB ID | NA
|