| Primary information |
|---|
| ID | 33131 |
| Uniprot ID | P30530 |
| Description | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion. |
| Function | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival; cell proliferation; migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand; AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1; PIK3R2 and PIK3R3; but also GRB2; PLCG1; LCK and PTPN11. Other downstream substrate candidates for AXL are CBL; NCK2; SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis; optimal cytokine signaling during human natural killer cell development; hepatic regeneration; gonadotropin-releasing hormone neuron survi |
| Length | 894 |
| Molecular Weight | 98337 |
| Reference | 2247464; 1656220; 18 |
| Hormone | NA |
| PDB ID | NA
|