| Primary information |
|---|
| ID | 33115 |
| Uniprot ID | P06756 |
| Description | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into- Integrin alpha-V heavy chain; Integrin alpha-V light chain] |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction; focal adhesion |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | NA |
| Function | The alpha-V (ITGAV) integrins are receptors for vitronectin; cytotactin; fibronectin; fibrinogen; laminin; matrix metalloproteinase-2; osteopontin; osteomodulin; prothrombin; thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV-ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling |
| Length | 1048 |
| Molecular Weight | 116038 |
| Reference | 2443500; 10965141; 1 |
| Hormone | NA |
| PDB ID | NA
|