| Primary information |
|---|
| ID | 33114 |
| Uniprot ID | Q9UEF7 |
| Description | Klotho (EC 3.2.1.31) [Cleaved into- Klotho peptide] |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | [Isoform 1]- Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | N-glycosylated. |
| Function | May have weak glycosidase activity towards glucuronylated steroids. However; it lacks essential active site Glu residues at positions 239 and 872; suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. |
| Length | 1012 |
| Molecular Weight | 116181 |
| Reference | 9363890; 9464267; 15 |
| Hormone | NA |
| PDB ID | NA
|