| Primary information |
|---|
| ID | 33110 |
| Uniprot ID | P22455 |
| Description | Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internaliz |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | N-glycosylated. Full maturation of the glycan chains in the Golgi is essential for high affinity interaction with FGF19.; Ubiquitinated. Subject to proteasomal degradation when not fully glycosylated. |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation; differentiation and migration; and in regulation of lipid metabolism; bile acid biosynthesis; glucose uptake; vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1; the rate-limiting enzyme in bile acid synthesis; in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2; GAB1; PIK3R1 and SOS1; and mediates activation of RAS; MAPK1/ERK2; MAPK3/ERK1 and the MAP kinase signaling pathway; as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is |
| Length | 802 |
| Molecular Weight | 87954 |
| Reference | 1709094; 7680645; 10 |
| Hormone | NA |
| PDB ID | NA
|