| Primary information |
|---|
| ID | 33108 |
| Uniprot ID | P21802 |
| Description | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detec |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on several tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer. Phosphorylation at Tyr-769 is essential for interaction with PLCG1. |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation; differentiation; migration and apoptosis; and in the regulation of embryonic development. Required for normal embryonic patterning; trophoblast function; limb bud development; lung morphogenesis; osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation; proliferation and apoptosis; and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts; but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1; FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2; GAB1; PIK3R1 and SOS1; and mediates activatio |
| Length | 821 |
| Molecular Weight | 92025 |
| Reference | 1697263; 2172978; 16 |
| Hormone | NA |
| PDB ID | NA
|