| Primary information |
|---|
| ID | 33105 |
| Uniprot ID | P06213 |
| Description | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into- Insulin receptor subunit alpha; Insulin receptor subunit beta] |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | After being transported from the endoplasmic reticulum to the Golgi apparatus; the single glycosylated precursor is further glycosylated and then cleaved; followed by its transport to the plasma membrane. |
| Function | Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates; including; insulin receptor substrates (IRS1; 2; 3; 4); SHC; GAB1; CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues; including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways- the PI3K-AKT/PKB pathway; which is responsible for most of the metabolic actions of insulin; and the Ras-MAPK pathway; which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3; 4; 5) |
| Length | 1382 |
| Molecular Weight | 156333 |
| Reference | 2859121; 2983222; 22 |
| Hormone | NA |
| PDB ID | NA
|