| Primary information |
|---|
| ID | 33104 |
| Uniprot ID | P25445 |
| Description | Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | [Isoform 1]- Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Post Translational Modification | (Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1- arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. |
| Function | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance; in the antigen-stimulated suicide of mature T-cells; or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). |
| Length | 335 |
| Molecular Weight | 37732 |
| Reference | 1713127; 1375228; 75 |
| Hormone | NA |
| PDB ID | NA
|