| Primary information |
|---|
| ID | 33091 |
| Uniprot ID | Q13635 |
| Description | Protein patched homolog 1 (PTC) (PTC1) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | In the embryo; found in all major target tissues of sonic hedgehog; such as the ventral neural tube; somites; and tissues surrounding the zone of polarizing activity of the limb bud. |
| Similarity | NA |
| Post Translational Modification | Glycosylation is necessary for SHH binding. |
| Function | Acts as a receptor for sonic hedgehog (SHH); indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function; as inactivation of this protein is probably a necessary; if not sufficient step for tumorigenesis. |
| Length | 1447 |
| Molecular Weight | 160545 |
| Reference | 8658145; 8647801; 15 |
| Hormone | NA |
| PDB ID | NA
|