| Primary information |
|---|
| ID | 33072 |
| Uniprot ID | Q99788 |
| Description | Chemerin-like receptor 1 (Chemokine-like receptor 1) (G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ) |
| Organism | Homo sapiens |
| Txonomy | Homo ; Homininae ; Hominidae ; Hominoidea ; Catarrhini ; Simiiformes ; Haplorrhini ; Primates ; Euarchontoglires ; Boreoeutheria ; Eutheria ; Theria ; Mammalia ; Amniota ; Tetrapoda ; Dipnotetrapodomorpha ; Sarcopterygii ; Euteleostomi ; Teleostomi ; Gnathostomata ; Vertebrata ; Craniata ; Chordata ; Deuterostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | Cell membrane |
| Developmental Stage | Expressed during bone development. |
| Similarity | NA |
| Post Translational Modification | NA |
| Function | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization; phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2); TYRO3; MAPK14/P38MAPK and PI3K leading to multifunctional effects; like; reduction of immune responses; enhancing of adipogenesis and angionesis PubMed-27716822. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. |
| Length | 373 |
| Molecular Weight | 42322 |
| Reference | 9144535; 9603476; 14 |
| Hormone | NA |
| PDB ID | NA
|